Summary: For all patients with VTE, DOACs were associated with lower IRs of major bleeds, CRNM bleeds, and recurrent VTE compared to warfarin.
| Outcomes | All patients (N = 51,871) | ||||
|---|---|---|---|---|---|
| DOAC (n = 22,983) | Warfarin (n = 28,888) | P value† | |||
| n (%) | IR* (95% CI) | n (%) | IR* (95% CI) | ||
| Major bleed | 284 (1.2) | 39.2 (34.9-44.0) | 492 (1.7) | 65.1 (59.6-71.1) | <.0001 |
| CRNM bleed | 1405 (6.1) | 201.4 (191.1-212.2) | 1716 (5.9) | 236.0 (225.1-247.5) | <.0001 |
| Recurrent VTE | 228 (1.0) | 31.4 (27.6-35.7) | 323 (1.1) | 42.7 (38.3-47.6) | .0004 |
