Summary: For patients with BMI ≥25 to <30 kg/m2, DOACs were associated with lower IRs of major bleeds and recurrent VTE, and a similar IR of
CRNM bleeds, compared to warfarin.
CRNM bleeds, compared to warfarin.
| Outcomes | BMI ≥25 to <30 kg/m2 (N=16,840) | ||||
|---|---|---|---|---|---|
| DOAC (n = 7815) | Warfarin (n = 9025) | P value† | |||
| n (%) | IR* (95% CI) | n (%) | IR* (95% CI) | ||
| Major bleed | 100 (1.3) | 40.3 (33.1-49.0) | 159 (1.8) | 67.6 (57.9-79.0) | <.0001 |
| CRNM bleed | 478 (6.1) | 200.2 (183.0-218.9) | 511 (5.7) | 225.8 (207.1-246.3) | .06 |
| Recurrent VTE | 76 (1.0) | 30.5 (24.4-38.2) | 99 (1.1) | 42.0 (34.5-51.1) | .04 |
