Summary: For patients with BMI <25 kg/m2, DOACs were associated with a lower IR of major bleeds, and similar IRs of CRNM bleeds and
recurrent VTE, compared to warfarin.
recurrent VTE, compared to warfarin.
| Outcomes | BMI <25 kg/m2 (N = 10,334) | ||||
|---|---|---|---|---|---|
| DOAC (n = 4549) | Warfarin (n = 5785) | P value† | |||
| n (%) | IR* (95% CI) | n (%) | IR* (95% CI) | ||
| Major bleed | 75 (1.7) | 55.6 (44.3-69.7) | 123 (2.1) | 87.9 (73.7-104.9) | .0015 |
| CRNM bleed | 356 (7.8) | 277.8 (250.3-308.1) | 410 (7.1) | 307.1 (278.7-338.3) | .17 |
| Recurrent VTE | 48 (1.1) | 35.5 (26.7-47.1) | 63 (1.1) | 44.9 (35.0-57.4) | .22 |
