Summary: For patients with BMI ≥35 to <40 kg/m2, DOACs were associated with lower IRs of major bleeds and CRNM bleeds, and a similar IR of
recurrent VTE, compared to warfarin.
recurrent VTE, compared to warfarin.
| Outcomes | BMI ≥35 to <40 kg/m2 (N = 6702) | ||||
|---|---|---|---|---|---|
| DOAC (n = 2896) | Warfarin (n = 3806) | P value† | |||
| n (%) | IR* (95% CI) | n (%) | IR* (95% CI) | ||
| Major bleed | 35 (1.2) | 37.3 (26.8-52.0) | 69 (1.8) | 67.0 (52.9-84.8) | .0041 |
| CRNM bleed | 148 (5.1) | 163.1 (138.9-191.6) | 245 (6.4) | 247.4 (218.3-280.4) | .0001 |
| Recurrent VTE | 32 (1.1) | 34.1 (24.1-48.2) | 47 (1.2) | 45.7 (34.3-60.8) | .20 |
