• A multivariable generalized linear mixed model, with random effect for site, was used to determine the association of clinical variables with DOAC prescription, as compared with warfarin, in patients who weigh ≥120 kg and whose BMI ≥40 kg/m2, separately
  • The IRs for major bleeding, CRNM bleeding, and recurrent VTE by DOAC and warfarin prescription status and by weight and BMI categories were determined separately, and differences between groups IRs were compared using the mid-P exact test
  • A multivariable Cox proportional hazard model with shared frailty was used to adjust for the site to determine the following
    • The association of weight categories to clinical outcomes in patients prescribed DOAC
    • The association of DOAC prescription to clinical outcomes as compared to warfarin by weight and
      BMI categories