Summary: For patients weighing ≥60 to <100 kg, DOACs were associated with lower IRs of major bleeds, CRNM bleeds, and recurrent VTE compared to warfarin.
| Outcomes | Weight ≥60 to <100 kg (N = 30,645) | ||||
|---|---|---|---|---|---|
| DOAC (n = 13,924) | Warfarin (n = 16,721) | P value† | |||
| n (%) | IR* (95% CI) | n (%) | IR* (95% CI) | ||
| Major bleed | 184 (1.3) | 42.4 (36.7-49.0) | 298 (1.8) | 69.6 (62.2-78.0) | <.0001 |
| CRNM bleed | 881 (6.3) | 211.4 (197.9-225.8) | 1031 (6.2) | 251.0 (236.2-266.8) | .0002 |
| Recurrent VTE | 138 (1.0) | 31.7 (26.8-37.5) | 175 (1.1) | 40.8 (35.2-47.3) | .0268 |
