ADVANCE-1, Apixaban with enoxaparin for thromboprophylaxis after knee replacement; ADVANCE-2, Apixaban versus enoxaparin for thromboprophylaxis after knee replacement; ADVANCE-3, Apixaban versus enoxaparin for thromboprophylaxis after hip replacement; AMPLIFY, Apixaban for the Initial Management of Pulmonary Embolism and Deep-Vein Thrombosis as First-Line Therapy; AMPLIFY-EXT, Apixaban after the Initial Management of Pulmonary Embolism and Deep Vein Thrombosis with First-Line Therapy–Extended Treatment; ARISTOTLE, Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation; AVERROES, Apixaban Versus Acetylsalicylic Acid to Prevent Stroke in Atrial Fibrillation Patients Who Have Failed or Are Unsuitable for Vitamin K Antagonist Treatment.