Summary: For patients weighing ≥120 kg, chronic kidney disease was associated with increased odds of a DOAC prescription, while weight and diabetes were
associated with increased odds of a warfarin prescription. Associations between clinical variables and DOAC prescription in those with BMI ≥40 kg/m2 were
similar to associations for those ≥120 kg.
  Weight ≥120 kg BMI ≥40 kg/m2
Variables OR* (95% CI) P value OR* (95% CI) P value
Age (years)† 0.93 (0.78-1.11) .41 1.03 (0.97-1.10) .34
Sex (woman) 1.04 (0.44-2.46) .93 0.98 (0.78-1.23) .86
Race (White) 1.11 (0.73-1.70) .62 1.17 (0.99-1.38) .07
Weight (kg)† 0.76 (0.66-0.88) .0003 0.93 (0.90-0.96) <.0001
Coronary artery disease 0.99 (0.56-1.73) .96 0.94 (0.76-1.16) .42
Chronic kidney disease 2.85 (1.80-4.51) <.0001 2.39 (1.98-2.87) <.0001
Diabetes mellitus 0.62 (0.39-0.98) .0410 0.54 (0.45-0.65) <.0001
Heart failure 0.82 (0.41-1.65) .59 0.93 (0.74-1.16) .51
Hypertension 0.84 (0.56-1.73) .42 0.84 (0.72-0.97) .02
PAD 1.25 (0.60-2.62) .55 0.79 (0.57-1.09) .15
Prior MI 0.85 (0.24-3.04) .81 0.65 (0.39-1.08) .09
Stroke/TIA 0.45 (0.11-1.89) .28 0.58 (0.38-0.89) .02