Summary: For patients weighing <60 kg, DOACs were associated with similar IRs of major bleeds, CRNM bleeds, and recurrent VTE compared to warfarin.
| Outcomes | Weight <60 kg (N = 1632) | ||||
|---|---|---|---|---|---|
| DOAC (n = 713) | Warfarin (n = 919) | P value† | |||
| n (%) | IR* (95% CI) | n (%) | IR* (95% CI) | ||
| Major bleed | 16 (2.2) | 78.9 (48.3-128.8) | 30 (3.3) | 145.3 (101.6-207.8) | .05 |
| CRNM bleed | 64 (9.0) | 335.0 (262.2-428.0) | 71 (7.7) | 362.9 (287.6-458.0) | .64 |
| Recurrent VTE | 8 (1.1) | 39.1 (19.7-78.6) | 7 (0.8) | 33.6 (16.0-70.4) | .77 |
