Summary: For patients with BMI ≥25 to <30 kg/m2, DOACs were associated with lower IRs of major bleeds and recurrent VTE, and a similar IR of CRNM bleeds, compared to warfarin.
| Outcomes | BMI ≥30 to <35 kg/m2 (N = 13,768) | ||||
|---|---|---|---|---|---|
| DOAC (n = 6201) | Warfarin (n = 7567) | P value† | |||
| n (%) | IR* (95% CI) | n (%) | IR* (95% CI) | ||
| Major bleed | 60 (1.0) | 30.3 (23.5-39.0) | 99 (1.3) | 48.9 (40.1-59.5) | .0031 |
| CRNM bleed | 327 (5.3) | 170.6 (153.0-190.1) | 402 (5.3) | 200.7 (186.5-226.8) | .01 |
| Recurrent VTE | 58 (0.9) | 29.2 (22.5-37.8) | 82 (1.1) | 40.5 (32.6-50.3) | .06 |
