Plasma concentration versus time profile of Apixaban
(single oral 10-mg dose) by body weight group
(single oral 10-mg dose) by body weight group
Concentration (ng/mL)
400
350
300
250
200
150
100
50
0
Time (hours)
0
8
16
24
32
40
48
56
64
72
Low ≤50 kg, (n = 18)Reference 65 to 85 kg, (n = 16)
High ≥120 kg, (n = 19)
Relationship between Apixaban plasma concentration and anti-factor Xa activity by body weight group
Anti-Xa activity (U/mL; LMWH)
6
5
4
3
2
1
0
Apixaban concentraction (ng/mL)
0
50
100
150
200
250
300
350
400
Low ≤50 kg, (n = 18)Reference 65 to 85 kg, (n = 16)
High ≥120 kg, (n = 19)
Authors’ summary
- For apixaban plasma concentration, there was a trend toward lower plasma anti-factor Xa activity with increasing body weight
- Anti-factor Xa activity showed a direct linear relationship with apixaban plasma concentration that was consistent across the body weight groups
