Summary: For patients weighing ≥120 kg to <140 kg, DOACs were associated with lower IRs of major bleeds and CRNM bleeds, and a similar IR of
recurrent VTE, compared to warfarin.
Outcomes Weight ≥120 to <140 kg (N = 4767)
DOAC (n = 1938) Warfarin (n = 2829) P value
n (%) IR* (95% CI) n (%) IR* (95% CI)
Major bleed 21 (1.1) 33.2 (21.7-51.0) 47 (1.7) 60.0 (45.1-79.8) .0217
CRNM bleed 101 (5.2) 164.3 (135.2-199.6) 179 (6.3) 239.2 (206.6-276.9) .0022
Recurrent VTE 19 (1.0) 30.1 (19.2-47.1) 36 (1.3) 46.1 (33.3-63.9) .13
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