Summary: For patients weighing ≥120 kg to <140 kg, DOACs were associated with lower IRs of major bleeds and CRNM bleeds, and a similar IR of
recurrent VTE, compared to warfarin.
recurrent VTE, compared to warfarin.
Outcomes | Weight ≥120 to <140 kg (N = 4767) | ||||
---|---|---|---|---|---|
DOAC (n = 1938) | Warfarin (n = 2829) | P value† | |||
n (%) | IR* (95% CI) | n (%) | IR* (95% CI) | ||
Major bleed | 21 (1.1) | 33.2 (21.7-51.0) | 47 (1.7) | 60.0 (45.1-79.8) | .0217 |
CRNM bleed | 101 (5.2) | 164.3 (135.2-199.6) | 179 (6.3) | 239.2 (206.6-276.9) | .0022 |
Recurrent VTE | 19 (1.0) | 30.1 (19.2-47.1) | 36 (1.3) | 46.1 (33.3-63.9) | .13 |