Summary: For patients weighing ≥100 to <120 kg, DOACs were associated with the decreased IRs of major bleeds and recurrent VTE, and a similar IR of
CRNM bleeds, compared to warfarin.
CRNM bleeds, compared to warfarin.
Outcomes | Weight ≥100 to <120 kg (N = 12,660) | ||||
---|---|---|---|---|---|
DOAC (n = 5683) | Warfarin (n = 6977) | P value† | |||
n (%) | IR* (95% CI) | n (%) | IR* (95% CI) | ||
Major bleed | 56 (1.0) | 30.5 (23.5-39.6) | 98 (1.4) | 51.8 (42.5-63.2) | .0013 |
CRNM bleed | 316 (5.6) | 178.3 (159.7-199.1) | 363 (5.2) | 198.5 (179.1-220.0) | .16 |
Recurrent VTE | 53 (0.9) | 28.8 (22.0-37.7) | 90 (1.3) | 47.6 (38.7-58.6) | .0033 |