Summary: For patients weighing ≥100 to <120 kg, DOACs were associated with the decreased IRs of major bleeds and recurrent VTE, and a similar IR of
CRNM bleeds, compared to warfarin.
Outcomes Weight ≥100 to <120 kg (N = 12,660)
DOAC (n = 5683) Warfarin (n = 6977) P value
n (%) IR* (95% CI) n (%) IR* (95% CI)
Major bleed 56 (1.0) 30.5 (23.5-39.6) 98 (1.4) 51.8 (42.5-63.2) .0013
CRNM bleed 316 (5.6) 178.3 (159.7-199.1) 363 (5.2) 198.5 (179.1-220.0) .16
Recurrent VTE 53 (0.9) 28.8 (22.0-37.7) 90 (1.3) 47.6 (38.7-58.6) .0033
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