Summary: In multivariable analyses, DOACs were not associated with an increased risk of major bleeding for those in higher weight categories
compared to those in the average weight category (≥60 to <100 kg).
Outcomes* Unadjusted† Adjusted†,‡
HR 95% CI P value HR 95% CI P value
Major bleed            
≥140 kg 0.71 0.33-1.51 .37 0.84 0.39-1.80 .65
≥120 to <140 kg 0.80 0.51-1.25 .33 0.89 0.56-1.41 .61
≥100 to <120 kg 0.73 0.54-0.99 .04 0.80 0.59-1.08 .14
<60 kg 1.79 1.08-2.99 .03 1.39 0.82-2.34 .22
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