Summary: DOACs were associated with a lower risk of major bleeding for patients in weight categories of ≥120 to <140 kg, ≥100 to <120 kg,
and ≥60 to <100 kg compared to warfarin.
Outcomes* Unadjusted† Adjusted†,‡
HR 95% CI P value HR 95% CI P value
Major bleed            
≥140 kg 0.65 0.27-1.55 .33 0.78 0.32-1.92 .60
≥120 to <140 kg 0.58 0.35-0.97 .04 0.54 0.32-0.91 .02
≥100 to <120 kg 0.64 0.46-0.89 .0078 0.70 0.50-0.98 .04
≥60 to <100 kg 0.66 0.55-0.79 <.0001 0.76 0.63-0.92 .0051
<60 kg 0.56 0.30-1.03 .06 0.65 0.35-1.23 .19
1|2|3|4|5|6|7|8|9|10|11|12