Summary: In multivariable analyses, DOACs were not associated with an increased risk of CRNM bleeding for those in higher weight categories
compared to those in the average weight category (≥60 to <100 kg).
Outcomes* Unadjusted† Adjusted†,‡
HR 95% CI P value HR 95% CI P value
CRNM bleed            
≥140 kg 0.90 0.66-1.23 .51 1.01 0.74-1.37 .97
≥120 to <140 kg 0.79 0.65-0.97 .03 0.85 0.68-1.04 .12
≥100 to <120 kg 0.86 0.75-0.98 .02 0.89 0.78-1.02 .09
<60 kg 1.53 1.19-1.97 .001 1.33 1.03-1.72 .03
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