Summary: In multivariable analyses, DOACs were not associated with an increased risk of CRNM bleeding for those in higher BMI categories compared to
those in the average weight category (≥60 to <100 kg).
Outcomes* Unadjusted† Adjusted†,‡
HR 95% CI P value HR 95% CI P value
CRNM bleed            
≥50 kg/m2 1.02 0.57-1.81 .95 1.16 0.65-2.07 .61
≥40 to <50 kg/m2 1.00 0.80-1.27 .95 1.04 0.82-1.32 .73
≥35 to <40 kg/m2 0.82 0.69-0.99 .04 0.86 0.71-1.03 .10
≥30 to <35 kg/m2 0.86 0.74-0.99 .03 0.87 0.75-1.00 .05
<25 kg/m2 1.36 1.18-1.56 <.0001 1.22 1.06-1.40 .0056
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