Apixaban in Obese Patients

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Risk of Recurrent VTE by BMI Category in Patients With VTE Prescribed DOACs Compared To Patients With BMI ≥25 to <30 kg/m^{2 1}

Perino 2021

Summary: In multivariable analyses, DOACs were not associated with an increased risk of recurrent VTE for those in higher BMI categories
compared to those in the average BMI category (≥25 to <30 kg/m²).

Outcomes*	Unadjusted^†			Adjusted^†,‡
Outcomes*	HR	95% CI	P value	HR	95% CI	P value
Recurrent VTE
≥50 kg/m²	0.54	0.07-3.85	.54	0.43	0.06-3.10	.40
≥40 to <50 kg/m²	0.99	0.55-1.79	.99	0.79	0.44-1.44	.44
≥35 to <40 kg/m²	1.13	0.75-1.71	.57	0.98	0.64-1.49	.91
≥30 to <35 kg/m²	0.96	0.68-1.35	.82	0.89	0.63-1.25	.49
<25 kg/m²	1.13	0.78-1.62	.52	1.11	0.77-1.60	.58

1|2|3|4|5|6|7|8|9|10|11|12

*Reference BMI ≥25 to <30 kg/m².
^†Cox proportional hazards models to adjust for site.
^‡A multivariable model includes age, sex, race, antiplatelet prescription, HAS-BLED score, CCI, and all baseline comorbidities (anemia, coronary artery disease, chronic kidney disease, diabetes, heart failure, hypertension, PAD, prior MI, prior stroke, or TIA).

BMI, body mass index; CCI, Charlson comorbidity index; CI, confidence interval; DOAC, direct oral anticoagulant HAS-BLED, hypertension, abnormal renal/liver function, stroke, bleeding history or predisposition, labile INR, elderly, drugs/alcohol concomitantly; HR, hazard ratio; MI, myocardial infarction; PAD, peripheral artery disease; TIA, transient ischemic attack;
VTE, venous thromboembolism.

Risk of Recurrent VTE by BMI Category in Patients With VTE Prescribed DOACs Compared To Patients With BMI ≥25 to <30 kg/m2 1

Risk of Recurrent VTE by BMI Category in Patients With VTE Prescribed DOACs Compared To Patients With BMI ≥25 to <30 kg/m^{2 1}