BMI ≤25 kg/m2 BMI >25-30 kg/m2 BMI >30-35 kg/m2 BMI >35-40 kg/m2 BMI >40 kg/m2
Total
N = 1442
Apix
n = 728
E/W
n =714
Total
N = 2045
Apix
n = 1005
E/W
n = 1040
Total
N = 1167
Apix
n = 580
E/W
n = 587
Total
n = 442
Apix
n = 236
E/W
n = 206
Total
N = 263
Apix
n = 126
E/W
n = 137
Age (years), mean (SD) 54.9
(18.4)
55.3
(18.5)
54.6
(18.4)
58.7
(15.4)
58.9
(15.4)
58.5
(15.5)
57.6
(14.3)
57.8
(14.4)
57.5
(14.3)
55.5
(14.3)
56.3
(14.3)
54.7
(14.2)
53.4
(13.3)
53.7
(13.4)
53.2
(13.2)
Women, n (%) 658
(45.6)
338
(46.4)
320
(44.8)
665
(32.5)
323
(32.1)
342
(32.9)
483
(41.4)
255
(44.0)
228
(38.8)
237
(53.6)
122
(51.7)
115
(55.8)
172
(65.4)
79
(62.7)
93
(67.9)
BMI (kg/m2), mean (SD) 22.6
(1.9)
22.7
(1.9)
22.6
(1.9)
27.4
(1.4)
27.4
(1.4)
27.4
(1.4)
32.0
(1.4)
32.0
(1.4)
32.0
(1.4)
37.0
(1.4)
37.0
(1.4)
37.0
(1.4)
45.3
(5.5)
45.2
(5.5)
45.3
(5.5)
CrCl (mL/min), n (%)
≤30 20
(1.4)
8
(1.1)
12
(1.7)
8
(0.4)
5
(0.5)
3
(0.3)
0
(0.0)
0
(0.0)
0
(0.0)
1
(0.2)
1
(0.4)
0
(0.0)
0
(0.0)
0
(0.0)
0
(0.0)
>30 to ≤50 135
(9.4)
72
(9.9)
63
(8.8)
126
(6.2)
64
(6.4)
62
(6.0)
37
(3.2)
20
(3.4)
17
(2.9)
7
(1.6)
3
(1.3)
4
(1.9)
3
(1.1)
2
(1.6)
1
(0.7)
>50 to ≤80 379
(26.3)
198
(27.2)
181
(25.4)
441
(21.6)
223
(22.2)
218
(21.0)
194
(16.6)
88
(15.2)
106
(18.1)
56
(12.7)
30
(12.7)
26
(12.6)
13
(4.9)
7
(5.6)
6
(4.4)
>80 784
(54.4)
390
(53.6)
394
(55.2)
1268
(62.0)
613
(61.0)
655
(63.0)
846
(72.5)
425
(73.3)
421
(71.7)
349
(79.0)
182
(77.1)
167
(81.1)
220
(83.7)
105
(83.3)
115
(83.9)
Not reported 124
(8.6)
60
(8.2)
64
(9.0)
202
(9.9)
100
(10.0)
102
(9.8)
90
(7.7)
47
(8.1)
43
(7.3)
29
(6.6)
20
(8.5)
9
(4.4)
27
(10.3)
12
(9.5)
15
(10.9)
1|2