• Summary statistics were determined for baseline characteristics using the mean (SD) for normally distributed
    variables and the median (IQR) for non-normally distributed variables and proportions (if categorical)
  • A Kaplan-Meier curve and log rank test were utilized to assess time to VTE recurrence and time to major bleeding
    event at 12 months
  • For multivariable analysis, the Cox proportional hazards model was used
    • Confounders were included in the model if they were different between groups with a P value <.1
    • Two models were utilized, the first with all potential confounding variables included and the second using a
      backward elimination model with a removal P value of .1
  • A subgroup analysis was conducted to evaluate the primary and relevant secondary outcomes in patients with a
    BMI >50 kg/m2 and/or weight >140 kg