In multivariable analyses, patients with NVAF, overweight status, and obesity were associated with a lower all-cause mortality and a lower risk of the composite of stroke or SE, MI, and all-cause mortality.
| Outcome BMI category, kg/m2 |
Number of patients in the analysis |
Events (%/year) |
HR (95% CI) BMI 18.5 to <25 kg/m2 as a reference |
P Value Effect of BMI category |
|
|---|---|---|---|---|---|
| Stroke/SE |
|
||||
| 18.5 to <25 | 4038 | 142 (2.01) | - |
|
|
| 25 to <30 | 6671 | 174 (1.43) | 0.86 (0.68-1.08) |
|
.18 |
| ≥30 | 7131 | 150 (1.11) | 0.79 (0.61-1.02) |
|
|
| All-Cause mortality |
|
||||
| 18.5 to <25 | 4038 | 397 (5.45) |
|
||
| 25 to <30 | 6671 | 429 (3.44) | 0.67 (0.59-0.78) |
|
<.0001 |
| ≥30 | 7131 | 398 (2.90) | 0.63 (0.54-0.74) |
|
|
| Stroke/SE/MI/Death |
|
||||
| 18.5 to <25 | 4038 | 510 (7.23) |
|
||
| 25 to <30 | 6671 | 598 (4.92) | 0.74 (0.65-0.84) |
|
<.0001 |
| ≥30 | 7131 | 554 (4.13) | 0.68 (0.60-0.78) |
|
|
| Major bleed |
|
||||
| 18.5 to <25 | 3984 | 217 (3.44) | - |
|
|
| 25 to <30 | 6618 | 270 (2.44) | 0.82 (0.68-0.99) |
|
.11 |
| ≥30 | 7074 | 281 (2.30) | 0.91 (0.74-1.10) |
|
|
HR
