Event Apixaban
(n = 4236) 		Enoxaparin
(n = 4228) 		Absolute risk difference
(Apixaban – Enoxaparin)
(95% CI) 		Interaction P value
Major VTE, % (n/N)
Overall 0.68 (23/3394) 1.50 (51/3394) -0.76 (- 1.23, - 0.30)
Body weight ≤ 60 kg 0.25 (1/404) 0.50 (2/400) - 0.25 (- 1.09, 0.59) .9335
Body weight > 60 kg 0.74 (22/2878) 1.64 (49/2988) - 0.84 ( -1.36, -0.33)
Major bleeding, % (n/N)
Overall 0.74 (31/4174) 0.77 (32/4167) - 0.02 (- 0.40, 0.35)
Body weight ≤ 60 kg 1.24 (6/484) 0.20 (1/497) 1.04 (- 0.02, 2.10) .0706
Body weight > 60 kg 0.68 (25/3677) 0.82 (30/3659) - 0.14 (- 0.53, 0.25)
Major + CRNM bleeding, % (n/N)
Overall 4.36 (182/4174) 4.94 (206/4167) - 0.58 (- 1.49, 0.32)
Body weight ≤ 60 kg 3.10 (15/484) 4.43 (22/497) - 1.32 (- 3.69, 1.06) .4433
Body weight > 60 kg 4.54 (167/3677) 4.97 (182/3659) - 0.44 (- 1.41, 0.54)
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