Warfarin Apixaban   HR (95% CI) P value for
interaction
No. of
events		 IR per 100
person-years		 No. of
events		 IR per 100
person-years
Recurrent VTE*              
Nonobese 1422 6.2 655 4.6
 
 0.72 (0.66-0.80) .170
Obese/Non-morbid 308 6.7 180 5.7
 
 0.83 (0.69-1.00)
Morbidly obese 350 8.1 125 5.3
 
 0.63 (0.52-0.78)
Major bleeding        
 
    
Nonobese 1315 5.7 564 4.0
 
 0.68 (0.62-0.76) .674
Obese/Non-morbid 287 6.2 152 4.8
 
 0.76 (0.62-0.94)
Morbidly obese 271 6.2 106 4.5
 
 0.70 (0.56-0.89)
CRNM bleeding        
 
    
Nonobese 6630 30.4 3522 26.1
 
 0.84 (0.80-0.88) .023
Obese/Non-morbid 1384 31.8 872 29.2
 
 0.90 (0.82-0.98)
Morbidly obese 1536 38.3 649 29.2
 
 0.75 (0.68-0.83)
0.5
0.6
0.7
0.8
0.9
1
1.1
1.2
Favors apixaban
Favors warfarin
1|2|3