Major Bleeding1,*
Event rate (%/year)
0.6
0.5
0.4
0.3
0.2
0.1
0.0
0.2
n = 2
0.1
0.5
n = 4
Apixaban 2.5 mg
N = 840
Apixaban 5 mg
N = 811
P = NS
Placebo
N = 826
Components of Major Bleeding2
Bleeding
outcome		 Apixaban
2.5 mg		 Apixaban
5 mg		 Placebo
  Number of events
Fatal bleeding 0 0 0
Major intraocular bleeding 2 0 1
Major GI bleeding 0 1 1
Intracranial bleeding 0 0 1
Major urogenital bleeding 0 0 1