Proportion of subjects with stroke or SE
0.05
0.04
0.03
0.02
0.01
0.00
Time to stroke or SE (months)
0
3
6
9
12
15
18
21
24
27
30
33
36
Warfarin
Apixaban
Apixaban: 212 patients, 1.27% per year
Warfarin: 265 patients, 1.60% per year
HR, 0.79 (95% CI: 0.66-0.95)
P (superiority) = .0114
No. at Risk
Apixaban 9120 8726 8440 6051 3464 1754 600
Warfarin 9081 8620 8301 5972 3405 1768 572