Apixaban in Obese Patients

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Characteristic	BMI <30 kg/m² (n = 296)	BMI ≥50 kg/m² (n = 299)	P value*
Age (years), median (IQR)	72.5 (57-81)	62 (54-70)	<.001
Non-Hispanic, White, n (%)	294 (99)	296 (99)	.999
Women, n (%)	136 (46)	188 (63)	<.001
BMI (kg/m²), median (IQR)	26.1 (23-28.3)	54.8 (52.2-61.4)	<.001
Weight (kg), median (IQR)	73.9 (64.2-84.4)	156.5 (138.6-177)	<.001
Height (inches), median (IQR)	67 (64-70)	65 (62-69)	<.001
CrCl (mL/min), median (IQR)^†	67.7 (42.5-97.5)	94.9 (71-130)	<.001
CHA₂DS₂-VASc score, median (IQR) Age ≥75 years, n (%) Age 65-74 years, n (%) Congestive heart failure, n (%) Hypertension, n (%) Diabetes, n (%) Stroke/TIA, n (%) MI, n (%) Peripheral arterial disease, n (%)	4 (3-5) 135 (46) 52 (18) 128 (43) 253 (85) 82 (28) 63 (21) 112 (38) 31 (10)	4 (3-5) 37 (12) 84 (28) 170 (57) 284 (95) 201 (67) 43 (14) 75 (25) 35 (12)	.394 <.001 .002 .001 <.001 <.001 .032 .011 .632

*To compare patients with a BMI ≥50 kg/m² and those with a BMI 18 to 30 kg/m², the Wilcoxon rank sum test was used for continuous variables and the Chi-square test or Fisher's exact test was used for categorical variables.
^†CrCl was calculated using the Cockcroft-Gault equation. The actual body weight was used for the BMI <30 kg/m² cohort, and the adjusted body weight was used for the BMI ≥50 kg/m² cohort.

BMI, body mass index; CHA₂DS₂-VASc, congestive heart failure, hypertension, age ≥75 (doubled), diabetes, stroke (doubled), vascular disease, age 65 to 74 and sex category (female); CrCl, creatinine clearance; IQR, interquartile range; MI, myocardial infarction; TIA, transient ischemic attack.

Baseline Characteristics1

Baseline Characteristics¹