• Compared outcome rates using Pearson x² or Fisher exact test; adjusted for differences in duration of follow-up via
    time-to-event analysis as well as differences in comorbidities, CHA2DS2-VASc score, and age where appropriate;
    and stratified analyses by OAC indication
  • Confirmed VTEs and strokes via review of imaging studies (e.g., compression ultrasonography, ventilation-perfusion
    scans, CT scans, and MRIs)
  • Measured safety as major bleeding and composite of major bleeding and CRNM bleeding per the Subcommittee on
    Control of Anticoagulation of the Scientific and Standardization Committee of the ISTH
  • Documented INR of warfarin patients on the day of, or the day before if no INR was recorded on the day of the
    event, a thrombotic or bleeding event, capturing values >20 without the discrete values
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